The ONTIME browser provides visualizations of summary statistics for Alzheimer's disease (AD) relevant phenotypes and proteomics data from the Neurogenomics and Informatics (NGI) group. These visualizations include Manhattan plots, PheWeb plots, and locuszoom plots.
The study associated with this data, Integration of multi-tissue proteomics with genomics in the human genome build 38 (currently unpublished) by Heng Yi et al., attempted to replicate the group's previous work—this time using HG-38 instead of HG-19 and contrasting the results of the two to see if the previous work was replicable and discover new findings.
Looking for the HG-19 ONTIME browser? It can be found here.
Related Reading:
- Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders Yang, et al (2021)
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing Kunkle, et al (2019)
- A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer’s disease Huang, et al (2017)
- Assessment of the genetic architecture of Alzheimer’s Disease risk in rate of memory decline Del-Aguila, et al (2018)
- Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging Yan, et al (2018)
- Genome-wide association study identifies four novel loci associated with Alzheimer’s endophenotypes and disease modifiers Deming, et al (2017)
- The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk Deming, et al (2018)
- The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion Li, et al (2020)
- Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies Nalls, et al (2019)
- Frontotemporal dementia and its subtypes: a genome-wide association study Ferrari, et al (2014)
